Linda C Burkly Selected Research

TWEAK Receptor

4/2017	Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice.
9/2015	Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival.
5/2015	Deficiency of fibroblast growth factor-inducible 14 (Fn14) preserves the filtration barrier and ameliorates lupus nephritis.
12/2013	Fn14 in podocytes and proteinuric kidney disease.
12/2011	Interleukin-13 damages intestinal mucosa via TWEAK and Fn14 in mice-a pathway associated with ulcerative colitis.
7/2011	Development of an Fn14 agonistic antibody as an anti-tumor agent.
12/2009	Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) enhances vascular and renal damage induced by hyperlipidemic diet in ApoE-knockout mice.
8/2009	TWEAK stimulation of kidney resident cells in the pathogenesis of graft versus host induced lupus nephritis.
4/2009	A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure.
4/2009	TNF-like weak inducer of apoptosis (TWEAK) induces inflammatory and proliferative effects in human kidney cells.

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Linda C Burkly Research Topics

Disease

15	Inflammation (Inflammations) 01/2021 - 08/2006
10	Fibrosis (Cirrhosis) 06/2017 - 04/2009
7	Neoplasms (Cancer) 09/2015 - 01/2002
6	Lupus Nephritis 09/2017 - 12/2006
5	Systemic Lupus Erythematosus (Libman-Sacks Disease) 11/2017 - 12/2006
5	Nephritis 11/2012 - 12/2006
4	Colitis 01/2016 - 03/2009
4	Atherosclerotic Plaque (Atheroma) 04/2014 - 12/2009
3	Necrosis 05/2016 - 01/2011
2	Disease Progression 09/2017 - 12/2016
2	Pathologic Processes 05/2015 - 08/2012
2	Proteinuria 12/2013 - 12/2007
2	Rheumatoid Arthritis 08/2013 - 08/2006
2	Kidney Diseases (Kidney Disease) 08/2009 - 02/2006
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2009 - 07/2004
2	Multiple Sclerosis 01/2009 - 02/2008
1	Ischemic Stroke 01/2021
1	Stroke (Strokes) 01/2021
1	Liver Cirrhosis (Hepatic Cirrhosis) 06/2017
1	Carcinoma (Carcinomatosis) 04/2017
1	Diarrhea 04/2017
1	Systemic Scleroderma (Systemic Sclerosis) 01/2017
1	Cachexia 09/2015
1	Weight Loss (Weight Reduction) 09/2015
1	Wounds and Injuries (Trauma) 09/2015
1	Abdominal Aortic Aneurysm 08/2014
1	Vascular Remodeling 08/2014
1	Aneurysm (Aneurysms) 08/2014
1	Morbid Obesity 06/2014
1	Atrophy 04/2014
1	Rupture 04/2014
1	Xanthomatosis (Xanthoma) 04/2014
1	Membranous Glomerulonephritis (Membranous Nephropathy) 12/2013
1	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 12/2013
1	Acute Kidney Injury (Acute Renal Failure) 10/2013
1	Acute Monocytic Leukemia (Acute Monoblastic Leukemia) 03/2013
1	Heart Failure 01/2013
1	Cardiomyopathies (Cardiomyopathy) 01/2013
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2013
1	Ulcerative Colitis 12/2011
1	Lymphopenia (Lymphocytopenia) 07/2011

Drug/Important Bio-Agent (IBA)

12	CytokinesIBA 01/2021 - 02/2006
12	TWEAK ReceptorIBA 04/2017 - 04/2005
11	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2014 - 01/2002
8	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2005
8	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 05/2016 - 10/2006
6	Cytokine TWEAKIBA 09/2015 - 12/2006
6	LigandsIBA 05/2015 - 10/2007
5	Monoclonal AntibodiesIBA 09/2014 - 07/2004
4	CollagenIBA 09/2017 - 04/2014
4	AntibodiesIBA 09/2015 - 01/2009
4	ChemokinesIBA 04/2014 - 02/2006
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2009
3	Small Interfering RNA (siRNA)IBA 06/2017 - 10/2006
3	Interleukin-13IBA 04/2017 - 12/2011
3	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 09/2014 - 10/2006
3	NF-kappa B (NF-kB)IBA 04/2014 - 10/2006
3	LipidsIBA 04/2014 - 11/2004
3	Chemokine CCL5IBA 11/2012 - 12/2006
2	Sulfonic AcidsIBA 09/2014 - 03/2009
2	DNA (Deoxyribonucleic Acid)IBA 04/2014 - 01/2009
2	Apolipoproteins E (ApoE)IBA 04/2014 - 12/2009
2	Messenger RNA (mRNA)IBA 12/2013 - 03/2013
2	AutoantibodiesIBA 08/2009 - 12/2007
1	ProteomeIBA 01/2021
1	dapirolizumab pegolIBA 11/2017
1	Peptides (Polypeptides)IBA 09/2017
1	Lipid NanoparticlesIBA 06/2017
1	Carbon Tetrachloride (Tetrachloromethane)IBA 06/2017
1	Fluorouracil (Carac)FDA LinkGeneric 04/2017
1	Interleukin-13 Receptors (Interleukin 13 Receptor)IBA 04/2017
1	Blocking AntibodiesIBA 12/2016
1	Becaplermin (PDGF-BB)FDA Link 01/2016
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2016
1	Dextrans (Dextran)FDA Link 01/2016
1	Hydroxyproline (4 Hydroxyproline)IBA 02/2015
1	Immunoglobulin G (IgG)IBA 09/2014
1	Peptide Hydrolases (Proteases)FDA Link 08/2014
1	Matrix Metalloproteinases (MMPs)IBA 08/2014
1	Pancreatic Elastase (Elastase)IBA 08/2014
1	Insulin (Novolin)FDA Link 06/2014
1	GATIBA 06/2014
1	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 06/2014
1	Muscle Proteins (Muscle Protein)IBA 04/2014
1	Transcription Factors (Transcription Factor)IBA 04/2014
1	Phenobarbital (Luminal)FDA Link 04/2014
1	CalciumIBA 04/2014
1	Metalloproteases (Metalloproteinases)IBA 04/2014
1	Cell Surface ReceptorsIBA 02/2014
1	BIIB023IBA 08/2013
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 03/2013
1	A-Form DNA (A-DNA)IBA 03/2013
1	HMGB1 Protein (HMG1)IBA 03/2013
1	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA 11/2012
1	Immunoglobulins (Immunoglobulin)IBA 11/2012
1	InterleukinsIBA 12/2011
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 07/2011
1	AntigensIBA 07/2011

Therapy/Procedure

1	Therapeutics 01/2021
1	Intravenous Injections 01/2013